Publications

Therapeutic Science

05. Nucleic acid-based technologies targeting coronaviruses

Le, T.K., Paris, C., Khan, K.S., Robson, F., Ng, W.-L.^# & Rocchi, P.^#(# Corresponding authors)

Trends in Biochemical Sciences, 2020.

Full article:
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(20)30295-4

04. Coronavirus RNA proofreading: molecular basis and therapeutic targeting

Robson, F., Khan, K.S., Le, T.K., Paris, C., Demirbag, S., Barfuss, P., Rocchi, P., Ng, W.-L.^#(# Corresponding author)

Molecular Cell, 2020.

Full article:
https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30518-9

03. Simeprevir suppresses SARS-CoV-2 replication and synergizes with remdesivir

Lo, H. S., Hui, K. P. Y., Lai, H. M., Khan, K. S., Kaur, S., Li, Z., Chan, A. K. N., Cheung, H. H. Y., Ng, K. C., Ho, C. W. J., Chen, Y. W., Ma, B., Cheung, M. H. P., Shin, D., Wang, K., Wu, K. P., Dikic, I., Liang, P. H., Zuo, Z., Chan, K. L. F., Hui, S. C. D., Mok, C. T. V., Wong, K. B., Ko, H., Aik, W. S., Chan, M. C. W. ^# & Ng, W.-L.^#(# Corresponding authors)

bioRxiv, 2020.

Full article:
https://www.biorxiv.org/content/10.1101/2020.05.26.116020v1

02. Epigenetic CRISPR screens identify Npm1 as a therapeutic vulnerability in non-small cell lung cancer

Li, F.*, Ng, W.-L.*, Luster, T. A., Hu, H., Sviderskiy, V.O., Dowling, C.M., Hollinshead, K.E.R., Zouitine, P., Zhang, H., Huang, Q., Ranieri, M., Wang, W., Fang, Z., Chen, T., Deng, J., Zhao, K., So, H.C., Khodadadi-Jamayran, A., Xu, M., Karatza, A., Pyon, V., Li, S., Pan, Y., Labbe, K., Almonte, C., Poirier, J.T., Miller, G., Possemato, R., Qi, J. & Wong, K.K. (*Co-first authors)

Cancer Res., 2020.

Full article:
https://cancerres.aacrjournals.org/content/early/2020/07/09/0008-5472.CAN-19-3782

01. In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma

Li, F., Huang, Q., Luster, T. A., Hu, H., Zhang, H., Ng, W.-L., Khodadadi-Jamayran, A., Wang, W., Chen, T., Deng, J., Ranieri, M., Fang, Z., Pyon, V., Dowling, C. M., Bagdatlioglu, E., Almonte, C., Labbe, K., Silver, H., Rabin, A. R., Jani, K., Tsirigos, A., Papagiannakopoulos, T., Hammerman, P. S., Velcheti, V., Freeman, G. J., Qi, J., Miller, G. & Wong, K.-K.

Cancer Discov., 2020

Full article:
https://cancerdiscovery.aacrjournals.org/content/early/2019/11/19/2159-8290.CD-19-0780

Chemical biology

05. Post-translational site-selective protein backbone α-deuteration

Galan, S. R. G., Wickens, J. R., Dadova, J., Ng, W.-L., Zhang, X., Simion, R. A., Quinlan, R., Pires, E., Paton, R. S., Caddick, S., Chudasama, V. & Davis, B. G.

Nat. Chem. Bio., 2018.

Full article:
https://www.nature.com/articles/s41589-018-0128-y

04. Selective Radical Trifluoromethylation of Native Residues in Proteins

Imiolek, M., Karunanithy, G., Ng, W.-L., Baldwin, A. J., Gouverneur, V. & Davis, B. G.

J. Am. Chem. Soc., 2018.

Full article:
https://doi.org/10.1021/jacs.7b10230

03. Chemical Probes for Visualizing Intact Animal and Human Brain Tissue

Lai, H. M., Ng, W.-L., Gentleman, S. M. & Wu, W.

Cell. Chem. Bio., 2017.

Full article:
https://doi.org/10.1016/j.chembiol.2017.05.015

02. Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity

Wright, T. H., Bower, B. J., Chalker, J. M., Bernardes, G. J., Wiewiora, R., Ng, W.-L., Raj, R., Faulkner, S., Vallee, M. R., Phanumartwiwath, A., Coleman, O. D., Thezenas, M. L., Khan, M., Galan, S. R., Lercher, L., Schombs, M. W., Gerstberger, S., Palm-Espling, M. E., Baldwin, A. J., Kessler, B. M., Claridge, T. D., Mohammed, S. & Davis, B. G.

Science, 2016.

Full article:
https://doi.org/10.1126/science.aag1465

01. Rationalisation and Validation of an Acrylamide-Free Procedure in Three-Dimensional Histological Imaging

Lai, H. M., Liu, A. K., Ng, W.-L., DeFelice, J., Lee, W. S., Li, H., Li, W., Ng, H. M., Chang, R. C., Lin, B., Wu, W. & Gentleman, S. M.

PLoS One, 2016.

Full article:
https://doi.org/10.1371/journal.pone.0158628

Medicinal Chemistry

05. Renewable Resource-Based Building Blocks/ Chirons for the Total Synthesis of Natural Products

Book Chapter in Efficiency in Natural Product Total Synthesis. P.-Q. Huang, Z.-J. Yao, R. P. Hsung., eds. Wiley, New York, 2018, 345.

Full article:
https://www.amazon.com/Efficiency-Natural-Product-Total-Synthesis/dp/1118605403

04. Synthetic and Biological Studies of Carbasugar SGLT2 Inhibitors (Invited Review)

Ng, W.-L. & Shing, T. K. M.

J. Syn. Org. Chem. Jpn., 2018.

Full article:
https://www.jstage.jst.go.jp/article/yukigoseikyokaishi/76/11/76_1215/_pdf/-char/en

03. Concise and Stereodivergent Synthesis of Carbasugars Reveals Unexpected Structure-Activity Relationship (SAR) of SGLT2 Inhibition

Ng, W.-L., Li, H. C., Lau, K. M., Chan, A. K. N., Lau, C. B. & Shing, T. K. M.

Sci. Rep., 2017.

Full article:
https://www.nature.com/articles/s41598-017-05895-9

02. Palladium-Catalyzed Arylation of Amino-Carbasugar Enables the Discovery of a Potent and Selective Carbocyclic SGLT2 Inhibitor

Ng, W.-L., Lau, K. M., Lau, C. B. & Shing, T. K. M.

Angew. Chem. Int. Ed., 2016.

Full article:
https://doi.org/10.1002/ange.201608758

01. Design, Syntheses and SAR Studies of Carbocyclic Analogues of Sergliflozin as Potent Sodium-dependent Glucose Co-transporter 2 Inhibitors

Shing, T. K. M.*, Ng, W.-L., Chan, J. Y. & Lau, C. B.

Angew. Chem. Int. Ed., 2013.

Full article:
https://doi.org/10.1002/anie.201302543