Publications

Therapeutic Science

04. Coronavirus RNA proofreading: molecular basis and therapeutic targeting

Fran Robson, Khadija Shahed Khan, Thi Khanh Le, Clément Paris, Sinem Demirbag, Peter Barfuss, Palma Rocchi, Wai-Lung Ng

Molecular Cell, 2020.

Full article:
https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30518-9

03. Simeprevir suppresses SARS-CoV-2 replication and synergizes with remdesivir

Ho Sing Lo, Kenrie P. Y. Hui, Hei-Ming Lai, Khadija Shahed Khan, Simranjeet Kaur, Zhongqi Li, Anthony K. N. Chan, Hayley Hei Yin Cheung, Ka Chun Ng, John Chi Wang Ho, Yu Wai Chen, Bowen Ma, Peter Man-Hin Cheung, Donghyuk Shin, Kaidao Wang, Kuen-Phon Wu, Ivan Dikic, Po-Huang Liang, Zhong Zuo, Francis K. L. Chan, David S. C. Hui, Vincent C.T. Mok, Kam-Bo Wong, Ho Ko, Wei Shen Aik, Michael C. W. Chan, Wai-Lung Ng

bioRxiv, 2020.

Full article:
https://www.biorxiv.org/content/10.1101/2020.05.26.116020v1

02. Epigenetic CRISPR screens identify Npm1 as a therapeutic vulnerability in non-small cell lung cancer

Fei Li*, Wai-Lung Ng*, Troy A. Luster, Hai Hu, Vladislav O. Sviderskiy, Catríona M. Dowling, Kate E. R. Hollinshead, Paula Zouitine, Hua Zhang, Qingyuan Huang, Michela Ranieri, Wei Wang, Zhaoyuan Fang, Ting Chen, Jiehui Deng, Kai Zhao, Hon-Cheong So, Alireza Khodadadi-Jamayran, Mousheng Xu, Angeliki Karatza, Val Pyon, Shuai Li, Yuanwang Pan, Kristen Labbe, Christina Almonte, John T. Poirier, George Miller, Richard Possemato, Jun Qi and Kwok-Kin Wong (*Co-first authors)

Cancer Res., 2020.

Full article:
https://cancerres.aacrjournals.org/content/early/2020/07/09/0008-5472.CAN-19-3782

01. In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma

Fei Li, Qingyuan Huang, Troy A Luster, Hai Hu, Hua Zhang, Wai-Lung Ng, Alireza Khodadadi-Jamayran, Wei Wang, Ting Chen, Jiehui Deng, Michela Ranieri, Zhaoyuan Fang, Val Pyon, Catriona M. Dowling, Ece Bagdatlioglu, Christina Almonte, Kristen Labbe, Heather Silver, Alexandra R Rabin, Kandarp Jani, Aristotelis Tsirigos, Thales Papagiannakopoulos, Peter S. Hammerman, Vamsidhar Velcheti, Gordon J. Freeman, Jun Qi, George Miller & Kwok-Kin Wong

Cancer Discov., 2019

Full article:
https://cancerdiscovery.aacrjournals.org/content/early/2019/11/19/2159-8290.CD-19-0780

Chemical biology

05. Post-translational site-selective protein backbone α-deuteration

Sébastien R. G. Galan, James R. Wickens, Jitka Dadova, Wai-Lung Ng, Xinglong Zhang, Robert A. Simion, Robert Quinlan, Elisabete Pires, Robert S. Paton, Stephen Caddick, Vijay Chudasama, Benjamin G. Davis

Nat. Chem. Bio., 2018, 14, 955.

Full article:
https://www.nature.com/articles/s41589-018-0128-y

04. Selective Radical Trifluoromethylation of Native Residues in Proteins

Mateusz Imiołek, Gogulan Karunanithy, Wai-Lung Ng, Andrew J. Baldwin, Véronique Gouverneur, Benjamin G. Davis

J. Am. Chem. Soc., 2018, 140, 1568.

Full article:
https://doi.org/10.1021/jacs.7b10230

03. Chemical Probes for Visualizing Intact Animal and Human Brain Tissue

Hei Ming Lai, Wai-Lung Ng, Steve M. Gentleman, Wutian Wu

Cell. Chem. Bio., 2017, 24, 659.

Full article:
https://doi.org/10.1016/j.chembiol.2017.05.015

02. Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity

Tom H. Wright, Ben J. Bower, Justin M. Chalker, Gonçalo J. L. Bernardes, Rafal Wiewiora, Wai-Lung Ng, Ritu Raj, Sarah Faulkner, M. Robert J. Vallée, Anuchit Phanumartwiwath, Oliver D. Coleman, Marie-Laëtitia Thézénas, Maola Khan, Sébastien R. G. Galan, Lukas Lercher, Matthew W. Schombs, Stefanie Gerstberger, Maria E. Palm-Espling, Andrew J. Baldwin, Benedikt M. Kessler, Timothy D. W. Claridge, Shabaz Mohammed, Benjamin G. Davis

Science, 2016, 354, 597.

Full article:
https://doi.org/10.1126/science.aag1465

01. Rationalisation and Validation of an Acrylamide-Free Procedure in Three-Dimensional Histological Imaging

Hei Ming Lai, Alan King Lun Liu, Wai-Lung Ng, John DeFelice, Wing Sang Lee, Heng Li, Wen Li, Ho Man Ng, Raymond Chuen-Chung Chang, Bin Lin, Wutian Wu, Steve M. Gentleman

PLoS One, 2016, 11, e0158628.

Full article:
https://doi.org/10.1371/journal.pone.0158628

Medicinal Chemistry

05. Renewable Resource-Based Building Blocks/ Chirons for the Total Synthesis of Natural Products

Book Chapter in Efficiency in Natural Product Total Synthesis. P.-Q. Huang, Z.-J. Yao, R. P. Hsung., eds. Wiley, New York, 2018, 345.

Full article:
https://www.amazon.com/Efficiency-Natural-Product-Total-Synthesis/dp/1118605403

04. Synthetic and Biological Studies of Carbasugar SGLT2 Inhibitors (Invited Review)

Wai-Lung Ng & Tony K. M. Shing

J. Syn. Org. Chem. Jpn., 2018, 76, 1215-1222.

Full article:
https://www.jstage.jst.go.jp/article/yukigoseikyokaishi/76/11/76_1215/_pdf/-char/en

03. Concise and Stereodivergent Synthesis of Carbasugars Reveals Unexpected Structure-Activity Relationship (SAR) of SGLT2 Inhibition

Wai-Lung Ng, Ho-Chuen Li, Kit-Man Lau, Anthony K. N. Chan, Clara Bik-San Lau & Tony K. M. Shing

Sci. Rep., 2017, 7, 5581.

Full article:
https://www.nature.com/articles/s41598-017-05895-9

02. Palladium-Catalyzed Arylation of Amino-Carbasugar Enables the Discovery of a Potent and Selective Carbocyclic SGLT2 Inhibitor

Wai‐Lung Ng, Kit‐Man Lau, Clara B.‐S. Lau, Tony K. M. Shing

Angew. Chem. Int. Ed., 2016, 55, 13818−13821.

Full article:
https://doi.org/10.1002/ange.201608758

01. Design, Syntheses and SAR Studies of Carbocyclic Analogues of Sergliflozin as Potent Sodium-dependent Glucose Co-transporter 2 Inhibitors

Tony K. M. Shing, Wai‐Lung Ng, Judy Y.‐W. Chan, Clara B.‐S. Lau

Angew. Chem. Int. Ed., 2013, 52, 8401−8405.

Full article:
https://doi.org/10.1002/anie.201302543