Selected Publications

For full list of publications, see Google Scholar Profile

^# First author, * Corresponding author

Targeted Control of Protein O-GlcNAcylation in Living Cells

Xu, T., Ng, B.W.-L*.

Glycobiology, 2026

Full article:
https://doi.org/10.1093/glycob/cwag081

Proximity-Induced Protein Deglycosylation by Endogenous O-GlcNAcase

Xu, H., Ma, B., Huang, Y., Liu, J., Ng, B.W.-L*.

Angewandte Chemie International Edition, 2026

Full article:
https://doi.org/10.1002/anie.1827729

Emerging chemical strategies for modulating protein O-GlcNAcylation

Wu. J., Ng, B.W.-L*.

Current Opinion in Chemical Biology, 2026

Full article:
https://doi.org/10.1016/j.cbpa.2026.102785

Chemically Induced Proximity for Targeted Protein O-GlcNAcylation

Ma, B.^#, Xu, T.^#, Guo, Z., Ng, B.W.-L*.

Accounts of Chemical Research, 2026

Full article:
https://doi.org/10.1021/acs.accounts.6c00453

Molecular Editing of Bilobalide: Expanding Chemical Space and Biological Opportunities

Scheeff, S.^#, Sillapachaiyaporn, C.^#, Ng, B.W.-L*.

ACS Bio & Med Chem Au, 2026

Full article:
https://doi.org/10.1021/acsbiomedchemau.6c00164

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)-Linked Neuroinflammation

Sillapachaiyaporn, C.^#, Wang, W.^#, Qin, Y.^#, Yan, L., Scheeff, S., He, X., Wu, Q., Lin, Y., Shang, J., Ye, X., Liu, J., Sun, K., Yeung, C.W., Huang, J., Chen, Z., Liu, X., Geng, Y., Au, S.W.N., Ip, B.Y., Ko, H., Ng, B.W.-L*.

Advanced Science, 2026

Full article:
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202600011

Rewiring c-Myc Transcriptional Activity with an O-GlcNAcylation Targeting Chimera (OGTAC)

Xu, T., Guo, Z., Khan, K.S., Huang, Y., Ma, B., Liu, J., Felsher, D.W., and Ng, B.W.-L.*

Cell Chemical Biology, 2026

Full article: 10.1016/j.chembiol.2026.08.008

Molecular Editing of Bilobalide: Regioselective C-Ring Lactam Formation

Wang, W.^#, Scheeff, S.^#, Hau, S. C.-K., Qin, Y., Sillapachaiyaporn, C., and Ng, B.W.-L.*

Organic Letters, 2026

Full article:
https://pubs.acs.org/doi/10.1021/acs.orglett.6c01262

Carbohydrate-Based Drug Discovery: Synthetic Strategies and Clinical Applications

Scheeff, S.^#, Arakelyan, J., and Ng, B.W.-L.*

Israel Journal of Chemistry, 2026

Full article:
https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.70017

Antiviral Profiling and Cellular Activation of Carbobicyclic Nucleoside Analogues

Scheeff, S.^#, Baguio, J.M.J.^#, Liang, B.Z.^#, Xeque Amada, J., Tao, K.P., De Jonghe, S., Persoons, L., Chow, T.H.Y., Tse, C.K.M., Wu, R.Y., Xu, X., Zuo, Z., Cheung, P.P-H., Chan, R.W.Y.C.*, and Ng, B.W.-L.*

Journal of Medicinal Chemistry, 2026

Full article:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02584

Ligand-Directed Self-Assembling Chimeras for Targeted Protein O-GlcNAcylation

Guo, Z.^#, Xu, T.^#, Khan, K.S.^#, Scheeff, S., Qin, Y., Yu, S.Y., Lo, R., Li, Y., Xie, Y., Ma, B., Huang, Y., Yip, H. Y-Y., Chung, C. Y-S., Tamura, T., Hamachi, I., and Ng, B.W.-L.*

ACS Chemical Biology, 2025

Full article:
https://pubs.acs.org/doi/full/10.1021/acschembio.5c00684

Targeted O-GlcNAcylation of CK2α Triggers Its Ubiquitin-Proteasome Degradation and Alters Downstream Phosphorylation

Xu, T.^#, Ma, B., Li, Y., Guo, Z., Zhang, M. and Ng, B.W.-L.*

ACS Chemical Biology, 2025

Full article:
https://pubs.acs.org/doi/full/10.1021/acschembio.5c00223

Lactone-to-Lactam Editing Alters the Pharmacology of Bilobalide

Jiang, X.^#, He, X.^#, Wong, J.^#, Scheeff, S., Hau, S. C., Wong, T., Qin, Y., Fan, C., Ma, B., Chung, N., Huang, J., Zhao, J., Yan, Y., Xiao, M., Song, X., Hui, T. K. C. Zuo, Z., Wu, W. K. K., Ko, H., Chow, K. H. M. and Ng, B.W.-L.*

JACS Au, 2024

Full article:
https://pubs.acs.org/doi/full/10.1021/jacsau.4c00416

Targeted Protein O-GlcNAcylation Using Bifunctional Small Molecules

Ma, B.^#, Khan, K. S.^#, Xu, T., Xeque Amada, J., Guo, Z., Huang, Y.,Yu Y., Henry L., Cheng A. S. L. , Ng, B.W.-L.*

J. Am. Chem. Soc., 2024

Full article:
https://pubs.acs.org/doi/10.1021/jacs.3c14380

Design and Synthesis of Carbobicyclic Nucleoside Analogues

Scheeff, S.^#, Wang, Y.^#, Lyu., M.^#, Ahmadabadi, B. N., Hau, C.-K.,Hui, K. C., Zhang, Y. F., Zuo, Z., Chan, W.-Y., Ng, B.W.-L.*

Organic Letters, 2023

Full article:
https://pubs.acs.org/doi/epdf/10.1021/acs.orglett.3c03590

Phase separation in viral infections

Li, H., Ernst, C., Kolonko-Adamska, M., Greb-Markiewicz, B., Man, J., Parissi, V. and Ng, B.W.-L.^*

Trends in Microbiology, 2022

Full article:

https://www.cell.com/trends/microbiology/fulltext/S0966-842X(22)00161-5

Simeprevir potently suppresses SARS-CoV-2 replication and synergizes with remdesivir

Lo, H. S., Hui, K. P. Y., Lai, H.-M., He, X., Khan, K. S., Kaur, S., Huang, J., Li, Z., Chan, A. K. N., Cheung, H. H.-Y., Ng, K.-C., Ho, J. C. W., Chen, Y. W., Ma, B., Cheung, P. M.-H., Shin, D., Wang, K., Lee, M.-H., Selisko, B., Eydoux, C., Guillemot, J.-C., Canard, B., Wu, K.-P., Liang, P.-H., Dikic, I., Zuo, Z., Chan, F. K. L., Hui, D. S. C., Mok, V. C. T., Wong, K.-B., Mok, C. K. P., Ko, H., Aik, W. S., Chan, M. C. W.*& Ng, B.W.-L.*

ACS Cent Sci, 2021.

Full article:
https://pubs.acs.org/doi/10.1021/acscentsci.0c01186

First available on bioRxiv:
https://www.biorxiv.org/content/10.1101/2020.05.26.116020v1

Nucleic acid-based technologies targeting coronaviruses

Le, T.K., Paris, C., Khan, K.S., Robson, F., Ng, B.W.-L.* & Rocchi, P.*

Trends in Biochemical Sciences, 2021.

Full article:
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(20)30295-4

Coronavirus RNA proofreading: molecular basis and therapeutic targeting

Robson, F., Khan, K.S., Le, T.K., Paris, C., Demirbag, S., Barfuss, P., Rocchi, P., Ng, B.W.-L.*

Molecular Cell, 2020.

Full article:
https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30518-9

Residue-Selective Protein C-Formylation via Sequential Difluoroalkylation-Hydrolysis

Imiołek, M., Isenegger, P. G., Ng, B.W.-L., Khan, A., Gouverneur, V., & Davis, B. G.

ACS Central Science, 2021.

Full article:

https://pubs.acs.org/doi/10.1021/acscentsci.0c01193

Epigenetic CRISPR screens identify Npm1 as a therapeutic vulnerability in non-small cell lung cancer

Li, F.^#, Ng, B.W.-L.^#, Luster, T. A., Hu, H., Sviderskiy, V.O., Dowling, C.M., Hollinshead, K.E.R., Zouitine, P., Zhang, H., Huang, Q., Ranieri, M., Wang, W., Fang, Z., Chen, T., Deng, J., Zhao, K., So, H.C., Khodadadi-Jamayran, A., Xu, M., Karatza, A., Pyon, V., Li, S., Pan, Y., Labbe, K., Almonte, C., Poirier, J.T., Miller, G., Possemato, R., Qi, J. & Wong, K.K.

Cancer Research., 2020.

Full article:
https://cancerres.aacrjournals.org/content/early/2020/07/09/0008-5472.CAN-19-3782

In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma

Li, F., Huang, Q., Luster, T. A., Hu, H., Zhang, H., Ng, B.W.-L., Khodadadi-Jamayran, A., Wang, W., Chen, T., Deng, J., Ranieri, M., Fang, Z., Pyon, V., Dowling, C. M., Bagdatlioglu, E., Almonte, C., Labbe, K., Silver, H., Rabin, A. R., Jani, K., Tsirigos, A., Papagiannakopoulos, T., Hammerman, P. S., Velcheti, V., Freeman, G. J., Qi, J., Miller, G. & Wong, K.-K.

Cancer Discovery., 2020

Full article:
https://cancerdiscovery.aacrjournals.org/content/early/2019/11/19/2159-8290.CD-19-0780

Synthetic and Biological Studies of Carbasugar SGLT2 Inhibitors (Invited Review)

Ng, B.W.-L. & Shing, T. K. M.

J. Syn. Org. Chem. Jpn., 2018.

Full article:
https://www.jstage.jst.go.jp/article/yukigoseikyokaishi/76/11/76_1215/_pdf/-char/en

Selective Radical Trifluoromethylation of Native Residues in Proteins

Imiolek, M., Karunanithy, G., Ng, B.W.-L., Baldwin, A. J., Gouverneur, V. & Davis, B. G.

J. Am. Chem. Soc., 2018.

Full article:
https://doi.org/10.1021/jacs.7b10230

Post-translational site-selective protein backbone α-deuteration

Galan, S. R. G., Wickens, J. R., Dadova, J., Ng, B.W.-L., Zhang, X., Simion, R. A., Quinlan, R., Pires, E., Paton, R. S., Caddick, S., Chudasama, V. & Davis, B. G.

Nat. Chem. Bio., 2018.

Full article:
https://www.nature.com/articles/s41589-018-0128-y

Concise and Stereodivergent Synthesis of Carbasugars Reveals Unexpected Structure-Activity Relationship (SAR) of SGLT2 Inhibition

Ng, B.W.-L., Li, H. C., Lau, K. M., Chan, A. K. N., Lau, C. B. & Shing, T. K. M.

Sci. Rep., 2017.

Full article:
https://www.nature.com/articles/s41598-017-05895-9

Palladium-Catalyzed Arylation of Amino-Carbasugar Enables the Discovery of a Potent and Selective Carbocyclic SGLT2 Inhibitor

Ng, B.W.-L., Lau, K. M., Lau, C. B. & Shing, T. K. M.

Angew. Chem. Int. Ed., 2016.

Full article:
https://doi.org/10.1002/ange.201608758

Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity

Wright, T. H., Bower, B. J., Chalker, J. M., Bernardes, G. J., Wiewiora, R., Ng, B.W.-L., Raj, R., Faulkner, S., Vallee, M. R., Phanumartwiwath, A., Coleman, O. D., Thezenas, M. L., Khan, M., Galan, S. R., Lercher, L., Schombs, M. W., Gerstberger, S., Palm-Espling, M. E., Baldwin, A. J., Kessler, B. M., Claridge, T. D., Mohammed, S. & Davis, B. G.

Science, 2016.

Full article:
https://doi.org/10.1126/science.aag1465

Design, Syntheses and SAR Studies of Carbocyclic Analogues of Sergliflozin as Potent Sodium-dependent Glucose Co-transporter 2 Inhibitors

Shing, T. K. M.*, Ng, B.W.-L., Chan, J. Y. & Lau, C. B.

Angew. Chem. Int. Ed., 2013.

Full article:
https://doi.org/10.1002/anie.201302543

Commentaries

A small molecule that reshapes the chromatin dynamics of FOXA1

Khan, K.S., Ng, B.W.-L.*

Molecular Cell, 2024.

Full article:
https://www.sciencedirect.com/science/article/pii/S1097276524008591

Discovery of chemical probes that perturb protein complexes using size exclusion chromatography and chemical proteomics.

Ng, B.W.-L., Xu, T., Guo, Z.

Molecular Cell, 2023.

Full article:
https://www.cell.com/molecular-cell/pdf/S1097-2765(23)00323-4.pdf

Viral Condensates: Making it hard to replicate

Ng, B.W.-L., Scheeff, S., Amada, J. X.

eLife, 2023.

Full article:
https://elifesciences.org/articles/88044

Patents

Ng, W.-L., Scheeff, S., Amada, J.X., Jiang, X., He, X.
Bilobalide Derivative Compounds for Treating Neurological Diseases and Cancers.
PCT Application No. PCT/CN2024/109675. Filing Date: August 3, 2024.
US Non-Provisional Application No. 18/793,753. Filing Date: August 3, 2024.
Ng, W.-L., Ma, B.
Compositions and Methods Related to Protein Labeling.
US Non-Provisional Application No. 18/667,437. Filing Date: May 17, 2024.
Cheng, S. L. A., Ng, W.-L., Sippl, W., Yang, W., Wang, J., Sun, P., Jung, M.
Compositions and Methods Involving HDAC Inhibitors.
US Provisional Application No. 63/399,852. Filing Date: August 22, 2022.
Ng, W.-L., Lyu, M., Scheeff, S.
Carbobicyclic Nucleosides for Treatment of Viral Infection.
US Non-Provisional Application No. 18/134,770. Filing Date: April 14, 2023.
PCT Application No. PCT/CN2023/088340. Filing Date: April 14, 2023.
CN Patent Application No. CN 119654311A. Filing Date: April 14, 2023.
Poon, E. N. Y., Ng, W.-L., Kwok, K. S. M., Lee, C.
Methods for Assessing Toxicity of a Compound.
US Non-Provisional Application No. 17/750,123. Filing Date: May 20, 2022.
Ng, W.-L., Chan, C. W. M., Ko, H., Lai, H. M., Lo, H. S., Khan, K. S.
Drug Repurposing for Treatment of Coronavirus.
US Provisional Application No. 63/027,620. Filing Date: May 20, 2020.
Ng, W.-L., Li, F., Chan, Y.-C., Shing, T. K. M., Cheung, M. H., Lo, H. S., Jiang, X.
Carbobicyclic Nucleosides and Methods for Treatment of Coronavirus.
US Provisional Application No. 62/299,029. Filing Date: March 16, 2020.
Ng, W.-L., Huang, J., Yan, Y. C. L., Poon, C. S. D., Li, H. Y.
Chemical Probes for In Vivo Non-Invasive Imaging.
US Provisional Application No. 62/729,998. Filing Date: Sept 11, 2018.
Shing, T. K. M., Ng, W.-L., Li, H.-C., Lau, K.-M., Chan, A. K. N., Lau, C. B.-S.
Compounds for Treating Diabetes.
US Patent No. 10,759,729. Grant Date: Sep 1, 2020.
CN Patent Application No. CN 108059589. Filing Date: Dec 12, 2016.