Publications

Therapeutic Science

05. Simeprevir potently suppresses SARS-CoV-2 replication and synergizes with remdesivir

Lo, H. S., Hui, K. P. Y., Lai, H.-M., He, X., Khan, K. S., Kaur, S., Huang, J., Li, Z., Chan, A. K. N., Cheung, H. H.-Y., Ng, K.-C., Ho, J. C. W., Chen, Y. W., Ma, B., Cheung, P. M.-H., Shin, D., Wang, K., Lee, M.-H., Selisko, B., Eydoux, C., Guillemot, J.-C., Canard, B., Wu, K.-P., Liang, P.-H., Dikic, I., Zuo, Z., Chan, F. K. L., Hui, D. S. C., Mok, V. C. T., Wong, K.-B., Mok, C. K. P., Ko, H., Aik, W. S., Chan, M. C. W.^#& Ng, W.-L.^#(# Corresponding authors)

ACS Cent Sci, 2021.

Full article:
https://pubs.acs.org/doi/10.1021/acscentsci.0c01186

First available on bioRxiv:
https://www.biorxiv.org/content/10.1101/2020.05.26.116020v1

04. Nucleic acid-based technologies targeting coronaviruses

Le, T.K., Paris, C., Khan, K.S., Robson, F., Ng, W.-L.^# & Rocchi, P.^#(# Corresponding authors)

Trends in Biochemical Sciences, 2021.

Full article:
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(20)30295-4

03. Coronavirus RNA proofreading: molecular basis and therapeutic targeting

Robson, F., Khan, K.S., Le, T.K., Paris, C., Demirbag, S., Barfuss, P., Rocchi, P., Ng, W.-L.^#(# Corresponding author)

Molecular Cell, 2020.

Full article:
https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30518-9

02. Epigenetic CRISPR screens identify Npm1 as a therapeutic vulnerability in non-small cell lung cancer

Li, F.*, Ng, W.-L.*, Luster, T. A., Hu, H., Sviderskiy, V.O., Dowling, C.M., Hollinshead, K.E.R., Zouitine, P., Zhang, H., Huang, Q., Ranieri, M., Wang, W., Fang, Z., Chen, T., Deng, J., Zhao, K., So, H.C., Khodadadi-Jamayran, A., Xu, M., Karatza, A., Pyon, V., Li, S., Pan, Y., Labbe, K., Almonte, C., Poirier, J.T., Miller, G., Possemato, R., Qi, J. & Wong, K.K. (*Co-first authors)

Cancer Res., 2020.

Full article:
https://cancerres.aacrjournals.org/content/early/2020/07/09/0008-5472.CAN-19-3782

01. In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma

Li, F., Huang, Q., Luster, T. A., Hu, H., Zhang, H., Ng, W.-L., Khodadadi-Jamayran, A., Wang, W., Chen, T., Deng, J., Ranieri, M., Fang, Z., Pyon, V., Dowling, C. M., Bagdatlioglu, E., Almonte, C., Labbe, K., Silver, H., Rabin, A. R., Jani, K., Tsirigos, A., Papagiannakopoulos, T., Hammerman, P. S., Velcheti, V., Freeman, G. J., Qi, J., Miller, G. & Wong, K.-K.

Cancer Discov., 2020

Full article:
https://cancerdiscovery.aacrjournals.org/content/early/2019/11/19/2159-8290.CD-19-0780

Medicinal Chemistry

04. Synthetic and Biological Studies of Carbasugar SGLT2 Inhibitors (Invited Review)

Ng, W.-L. & Shing, T. K. M.

J. Syn. Org. Chem. Jpn., 2018.

Full article:
https://www.jstage.jst.go.jp/article/yukigoseikyokaishi/76/11/76_1215/_pdf/-char/en

03. Concise and Stereodivergent Synthesis of Carbasugars Reveals Unexpected Structure-Activity Relationship (SAR) of SGLT2 Inhibition

Ng, W.-L., Li, H. C., Lau, K. M., Chan, A. K. N., Lau, C. B. & Shing, T. K. M.

Sci. Rep., 2017.

Full article:
https://www.nature.com/articles/s41598-017-05895-9

02. Palladium-Catalyzed Arylation of Amino-Carbasugar Enables the Discovery of a Potent and Selective Carbocyclic SGLT2 Inhibitor

Ng, W.-L., Lau, K. M., Lau, C. B. & Shing, T. K. M.

Angew. Chem. Int. Ed., 2016.

Full article:
https://doi.org/10.1002/ange.201608758

01. Design, Syntheses and SAR Studies of Carbocyclic Analogues of Sergliflozin as Potent Sodium-dependent Glucose Co-transporter 2 Inhibitors

Shing, T. K. M.*, Ng, W.-L., Chan, J. Y. & Lau, C. B.

Angew. Chem. Int. Ed., 2013.

Full article:
https://doi.org/10.1002/anie.201302543

Chemical biology

06. Residue-Selective Protein C-Formylation via Sequential Difluoroalkylation-Hydrolysis

Imiołek, M., Isenegger, P. G., Ng, W. L., Khan, A., Gouverneur, V., & Davis, B. G.

ACS Central Science, 2021.

Full article:

https://pubs.acs.org/doi/10.1021/acscentsci.0c01193

05. Post-translational site-selective protein backbone α-deuteration

Galan, S. R. G., Wickens, J. R., Dadova, J., Ng, W.-L., Zhang, X., Simion, R. A., Quinlan, R., Pires, E., Paton, R. S., Caddick, S., Chudasama, V. & Davis, B. G.

Nat. Chem. Bio., 2018.

Full article:
https://www.nature.com/articles/s41589-018-0128-y

04. Selective Radical Trifluoromethylation of Native Residues in Proteins

Imiolek, M., Karunanithy, G., Ng, W.-L., Baldwin, A. J., Gouverneur, V. & Davis, B. G.

J. Am. Chem. Soc., 2018.

Full article:
https://doi.org/10.1021/jacs.7b10230

03. Chemical Probes for Visualizing Intact Animal and Human Brain Tissue

Lai, H. M., Ng, W.-L., Gentleman, S. M. & Wu, W.

Cell. Chem. Bio., 2017.

Full article:
https://doi.org/10.1016/j.chembiol.2017.05.015

02. Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity

Wright, T. H., Bower, B. J., Chalker, J. M., Bernardes, G. J., Wiewiora, R., Ng, W.-L., Raj, R., Faulkner, S., Vallee, M. R., Phanumartwiwath, A., Coleman, O. D., Thezenas, M. L., Khan, M., Galan, S. R., Lercher, L., Schombs, M. W., Gerstberger, S., Palm-Espling, M. E., Baldwin, A. J., Kessler, B. M., Claridge, T. D., Mohammed, S. & Davis, B. G.

Science, 2016.

Full article:
https://doi.org/10.1126/science.aag1465

01. Rationalisation and Validation of an Acrylamide-Free Procedure in Three-Dimensional Histological Imaging

Lai, H. M., Liu, A. K., Ng, W.-L., DeFelice, J., Lee, W. S., Li, H., Li, W., Ng, H. M., Chang, R. C., Lin, B., Wu, W. & Gentleman, S. M.

PLoS One, 2016.

Full article:
https://doi.org/10.1371/journal.pone.0158628