Therapeutic Science
05. Nucleic acid-based technologies targeting coronaviruses
Le, T.K., Paris, C., Khan, K.S., Robson, F., Ng, W.-L.# & Rocchi, P.#
(# Corresponding authors)
Trends in Biochemical Sciences, 2020.
Full article:
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(20)30295-4

04. Coronavirus RNA proofreading: molecular basis and therapeutic targeting
Robson, F., Khan, K.S., Le, T.K., Paris, C., Demirbag, S., Barfuss, P., Rocchi, P., Ng, W.-L.# (# Corresponding author)
Molecular Cell, 2020.
Full article:
https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30518-9

03. Simeprevir suppresses SARS-CoV-2 replication and synergizes with remdesivir
Lo, H. S., Hui, K. P. Y., Lai, H. M., Khan, K. S., Kaur, S., Li, Z., Chan, A. K. N., Cheung, H. H. Y., Ng, K. C., Ho, C. W. J., Chen, Y. W., Ma, B., Cheung, M. H. P., Shin, D., Wang, K., Wu, K. P., Dikic, I., Liang, P. H., Zuo, Z., Chan, K. L. F., Hui, S. C. D., Mok, C. T. V., Wong, K. B., Ko, H., Aik, W. S., Chan, M. C. W. # & Ng, W.-L.#
(# Corresponding authors)
bioRxiv, 2020.
Full article:
https://www.biorxiv.org/content/10.1101/2020.05.26.116020v1

02. Epigenetic CRISPR screens identify Npm1 as a therapeutic vulnerability in non-small cell lung cancer
Li, F.*, Ng, W.-L.*, Luster, T. A., Hu, H., Sviderskiy, V.O., Dowling, C.M., Hollinshead, K.E.R., Zouitine, P., Zhang, H., Huang, Q., Ranieri, M., Wang, W., Fang, Z., Chen, T., Deng, J., Zhao, K., So, H.C., Khodadadi-Jamayran, A., Xu, M., Karatza, A., Pyon, V., Li, S., Pan, Y., Labbe, K., Almonte, C., Poirier, J.T., Miller, G., Possemato, R., Qi, J. & Wong, K.K. (*Co-first authors)
Cancer Res., 2020.
Full article:
https://cancerres.aacrjournals.org/content/early/2020/07/09/0008-5472.CAN-19-3782

01. In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma
Li, F., Huang, Q., Luster, T. A., Hu, H., Zhang, H., Ng, W.-L., Khodadadi-Jamayran, A., Wang, W., Chen, T., Deng, J., Ranieri, M., Fang, Z., Pyon, V., Dowling, C. M., Bagdatlioglu, E., Almonte, C., Labbe, K., Silver, H., Rabin, A. R., Jani, K., Tsirigos, A., Papagiannakopoulos, T., Hammerman, P. S., Velcheti, V., Freeman, G. J., Qi, J., Miller, G. & Wong, K.-K.
Cancer Discov., 2020
Full article:
https://cancerdiscovery.aacrjournals.org/content/early/2019/11/19/2159-8290.CD-19-0780
