Therapeutic Science
05. Simeprevir suppresses SARS-CoV-2 replication and synergizes with remdesivir
Lo, H. S., Hui, K. P. Y., Lai, H.-M., He, X., Khan, K. S., Kaur, S., Huang, J., Li, Z., Chan, A. K. N., Cheung, H. H.-Y., Ng, K.-C., Ho, J. C. W., Chen, Y. W., Ma, B., Cheung, P. M.-H., Shin, D., Wang, K., Lee, M.-H., Selisko, B., Eydoux, C., Guillemot, J.-C., Canard, B., Wu, K.-P., Liang, P.-H., Dikic, I., Zuo, Z., Chan, F. K. L., Hui, D. S. C., Mok, V. C. T., Wong, K.-B., Mok, C. K. P., Ko, H., Aik, W. S., Chan, M. C. W.# & Ng, W.-L.#
(# Corresponding authors)
ACS Cent Sci, 2021.
Full article:
https://pubs.acs.org/doi/10.1021/acscentsci.0c01186
First available on bioRxiv:
https://www.biorxiv.org/content/10.1101/2020.05.26.116020v1
04. Nucleic acid-based technologies targeting coronaviruses
Le, T.K., Paris, C., Khan, K.S., Robson, F., Ng, W.-L.# & Rocchi, P.#
(# Corresponding authors)
Trends in Biochemical Sciences, 2021.
Full article:
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(20)30295-4
03. Coronavirus RNA proofreading: molecular basis and therapeutic targeting
Robson, F., Khan, K.S., Le, T.K., Paris, C., Demirbag, S., Barfuss, P., Rocchi, P., Ng, W.-L.# (# Corresponding author)
Molecular Cell, 2020.
Full article:
https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30518-9
02. Epigenetic CRISPR screens identify Npm1 as a therapeutic vulnerability in non-small cell lung cancer
Li, F.*, Ng, W.-L.*, Luster, T. A., Hu, H., Sviderskiy, V.O., Dowling, C.M., Hollinshead, K.E.R., Zouitine, P., Zhang, H., Huang, Q., Ranieri, M., Wang, W., Fang, Z., Chen, T., Deng, J., Zhao, K., So, H.C., Khodadadi-Jamayran, A., Xu, M., Karatza, A., Pyon, V., Li, S., Pan, Y., Labbe, K., Almonte, C., Poirier, J.T., Miller, G., Possemato, R., Qi, J. & Wong, K.K. (*Co-first authors)
Cancer Res., 2020.
Full article:
https://cancerres.aacrjournals.org/content/early/2020/07/09/0008-5472.CAN-19-3782
01. In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma
Li, F., Huang, Q., Luster, T. A., Hu, H., Zhang, H., Ng, W.-L., Khodadadi-Jamayran, A., Wang, W., Chen, T., Deng, J., Ranieri, M., Fang, Z., Pyon, V., Dowling, C. M., Bagdatlioglu, E., Almonte, C., Labbe, K., Silver, H., Rabin, A. R., Jani, K., Tsirigos, A., Papagiannakopoulos, T., Hammerman, P. S., Velcheti, V., Freeman, G. J., Qi, J., Miller, G. & Wong, K.-K.
Cancer Discov., 2020
Full article:
https://cancerdiscovery.aacrjournals.org/content/early/2019/11/19/2159-8290.CD-19-0780
